pentobarbital will minimize the level or impact of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Powerful or moderate CYP3A4 inducers drastically minimize guanfacine plasma concentrations and elimination 50 percent-daily life.
pentobarbital will reduce the extent or outcome of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a delicate CYP3A4 substrate. Coadministration with robust or moderate CYP3A4 inducers is contraindicated.
With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
pentobarbital will decrease the extent or result of nateglinide by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.
pentobarbital will lower the extent or result of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may well enhance the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will minimize the level or effect of oxybutynin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
pentobarbital will lessen the level or result of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. For people with ED, monitor response meticulously because of potential for diminished usefulness.
pentobarbital will reduce the level or effect of etonogestrel by impacting hepatic/intestinal enzyme website CYP3A4 metabolism. Use Warning/Watch.
Contraindicated (1)pentobarbital will reduce the extent or result of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Observe Carefully (1)pentobarbital will lower the level or impact of hydrocodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Caution when discontinuing CYP3A4 inducers which have been coadministered with hydrocodone; plasma concentrations of hydrocodone could enhance and may end up in most likely deadly respiratory depressionSerious - Use Substitute (one)hydrocodone, pentobarbital.
pentobarbital will lower the level or effect of amiodarone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Barbiturates can induce hepatic microsomal enzymes resulting in improved metabolism and diminished anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); individuals stabilized on anticoagulant therapy could call for dosage adjustments if barbiturates are included to or withdrawn from their dosage program
pentobarbital will reduce the extent or impact of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.